› 1ims

X-ray diffraction
1.5Å resolution

MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)

Released:
DOI: 10.2210/pdb1ims/pdb
PDB entry 1ims coloured by chain, front view.
PDB entry 1ims coloured by chain, side view.
PDB entry 1ims coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG).
Berger I, Su L, Spitzner JR, Kang C, Burke TG, Rich A
Nucleic Acids Res 23 4488-94 (1995)
PMID: 7501474

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113975 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM7 1 x DM7
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 27.73Å b: 27.73Å c: 52.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 not available
Expression system: Not provided

Quick links

Citations

7 citation in other articles

4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid.
Palha et al. (2000)
6 more

3 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
2 more