› 1imx

X-ray diffraction
1.82Å resolution

1.8 Angstrom crystal structure of IGF-1

Released:
DOI: 10.2210/pdb1imx/pdb
PDB entry 1imx coloured by chain, front view.
PDB entry 1imx coloured by chain, side view.
PDB entry 1imx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
Vajdos FF, Ultsch M, Schaffer ML, Deshayes KD, Liu J, Skelton NJ, de Vos AM
Biochemistry 40 11022-9 (2001)
PMID: 11551198

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor I Chain: A
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05019 (Residues: 49-118; Coverage: 40%)
Gene names: IBP1, IGF1
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like

Ligands and Environments

2 bound ligands:
Ligand BR 1 x BR
Ligand CPQ 1 x CPQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 31.831Å b: 71.055Å c: 65.996Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.245 0.258
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Structural biology of insulin and IGF1 receptors: implications for drug design.
De Meyts et al. (2002)
10 more

12 mentions without citation

Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step.
Weiskirchen R. (2015)
11 more