› 1irh

Solution NMR

The Solution Structure of The Third Kunitz Domain of Tissue Factor Pathway Inhibitor

Released:
DOI: 10.2210/pdb1irh/pdb
PDB entry 1irh coloured by chain, ensemble of 20 models, front view.
PDB entry 1irh coloured by chain, ensemble of 20 models, side view.
PDB entry 1irh coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor.
Mine S, Yamazaki T, Miyata T, Hara S, Kato H
Biochemistry 41 78-85 (2002)
PMID: 11772005

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tissue factor pathway inhibitor Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.92 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P10646 (Residues: 210-270; Coverage: 22%)
Gene names: LACI, TFPI, TFPI1
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Komagataella pastoris

Quick links

Citations

4 review citations

Regulation of functions of vascular wall cells by tissue factor pathway inhibitor: basic and clinical aspects.
Kato H. (2002)
3 more

4 mentions without citation

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick.
Macedo-Ribeiro et al. (2008)
3 more