› 1iss

X-ray diffraction
3.3Å resolution

Crystal Structure of Metabotropic Glutamate Receptor Subtype 1 Complexed with an antagonist

Released:
DOI: 10.2210/pdb1iss/pdb
PDB entry 1iss coloured by chain, front view.
PDB entry 1iss coloured by chain, side view.
PDB entry 1iss coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.
Tsuchiya D, Kunishima N, Kamiya N, Jingami H, Morikawa K
Proc Natl Acad Sci U S A 99 2660-5 (2002)
PMID: 11867751

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 490 amino acids
Theoretical weight: 55.26 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23385 (Residues: 33-522; Coverage: 42%)
Gene names: Gprc1a, Grm1, Mglur1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand MCG 2 x MCG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: P41212
Unit cell:
a: 112.142Å b: 112.142Å c: 289.905Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.257 0.314
Expression system: Spodoptera frugiperda

Quick links

Citations

72 review citations

Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Niswender et al. (2010)
71 more

3 mentions without citation

Metabotropic glutamate receptors: from the workbench to the bedside.
Nicoletti et al. (2011)
2 more