› 1ixt

Solution NMR

Structure of a Novel P-Superfamily Spasmodic Conotoxin Reveals an Inhibitory Cystine Knot Motif

Released:
DOI: 10.2210/pdb1ixt/pdb
PDB entry 1ixt coloured by chain, ensemble of 20 models, front view.
PDB entry 1ixt coloured by chain, ensemble of 20 models, side view.
PDB entry 1ixt coloured by chain, ensemble of 20 models, top view.
Source organism: Conus gloriamaris
Primary publication:
Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.
Miles LA, Dy CY, Nielsen J, Barnham KJ, Hinds MG, Olivera BM, Bulaj G, Norton RS
J Biol Chem 277 43033-40 (2002)
PMID: 12193600

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Conotoxin Gm9.1 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.81 KDa
Source organism: Conus gloriamaris
Expression system: Not provided
UniProt:
  • Canonical: Q9GU57 (Residues: 61-87; Coverage: 44%)
Sequence domains: Spasmodic peptide gm9a; conotoxin from Conus species

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: CNS, minimized in water
Expression system: Not provided

Quick links

Citations

3 review citations

Conotoxins down under.
Norton et al. (2006)
2 more

3 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
2 more