› 1j1b

X-ray diffraction
1.8Å resolution

Binary complex structure of human tau protein kinase I with AMPPNP

Released:
DOI: 10.2210/pdb1j1b/pdb
PDB entry 1j1b coloured by chain, front view.
PDB entry 1j1b coloured by chain, side view.
PDB entry 1j1b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.
Aoki M, Yokota T, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Ishiguro K, Kohno T, Sugio S, Matsuzaki T
Acta Crystallogr D Biol Crystallogr 60 439-46 (2004)
PMID: 14993667

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 46.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: P212121
Unit cell:
a: 82.8Å b: 86.3Å c: 178.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.242
Expression system: Escherichia coli

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Citations

11 citation in other articles

A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Buescher et al. (2010)
10 more

26 mentions without citation

Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches.
Cruz-Vicente et al. (2021)
25 more