› 1j42

X-ray diffraction
2.5Å resolution

Crystal Structure of Human DJ-1

Released:
DOI: 10.2210/pdb1j42/pdb
PDB entry 1j42 coloured by chain, front view.
PDB entry 1j42 coloured by chain, side view.
PDB entry 1j42 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.
Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS
J Biol Chem 278 44552-9 (2003)
PMID: 12939276

Function and Biology Details

Reaction catalysed: 
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parkinson disease protein 7 Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 19.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99497 (Residues: 1-189; Coverage: 100%)
Gene name: PARK7
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 75.075Å b: 75.075Å c: 75.158Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.228 0.249
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Molecular pathophysiology of Parkinson's disease.
Moore et al. (2005)
29 more

5 mentions without citation

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.
Kirchner et al. (2019)
4 more