› 1j5t

X-ray diffraction
3Å resolution

Crystal structure of indole-3-glycerol phosphate synthase (TM0140) from Thermotoga maritima at 3.0 A resolution

Released:
DOI: 10.2210/pdb1j5t/pdb
PDB entry 1j5t coloured by chain, front view.
PDB entry 1j5t coloured by chain, side view.
PDB entry 1j5t coloured by chain, top view.
Source organism: Thermotoga maritima
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reaction catalysed: 
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-176363 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Indole-3-glycerol phosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.51 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q56319 (Residues: 24-252; Coverage: 91%)
Gene names: TM_0140, trpC
Sequence domains: Indole-3-glycerol phosphate synthase
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: I4122
Unit cell:
a: 117.597Å b: 117.597Å c: 82.153Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.24 0.297
Expression system: Escherichia coli

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