› 1j7m

Solution NMR

The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2

Released:
DOI: 10.2210/pdb1j7m/pdb
PDB entry 1j7m coloured by chain, ensemble of 50 models, front view.
PDB entry 1j7m coloured by chain, ensemble of 50 models, side view.
PDB entry 1j7m coloured by chain, ensemble of 50 models, top view.
Source organism: Homo sapiens
Primary publication:
Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct.
Briknarová K, Gehrmann M, Bányai L, Tordai H, Patthy L, Llinás M
J Biol Chem 276 27613-21 (2001)
PMID: 11320090

Function and Biology Details

Reaction catalysed: 
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
72 kDa type IV collagenase Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08253 (Residues: 337-394; Coverage: 9%)
Gene names: CLG4A, MMP2
Sequence domains:
Structure domains: Fibronectin, type II, collagen-binding

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry and simulated annealing
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
Visse et al. (2003)
7 more

5 mentions without citation

A planarian nidovirus expands the limits of RNA genome size.
Saberi et al. (2018)
4 more