› 1jeb

X-ray diffraction
2.1Å resolution

Chimeric Human/Mouse Carbonmonoxy Hemoglobin (Human Zeta2 / Mouse Beta2)

Released:
DOI: 10.2210/pdb1jeb/pdb
PDB entry 1jeb coloured by chain, front view.
PDB entry 1jeb coloured by chain, side view.
PDB entry 1jeb coloured by chain, top view.
Source organisms:
Primary publication:
The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function.
Kidd RD, Russell JE, Watmough NJ, Baker EN, Brittain T
Biochemistry 40 15669-75 (2001)
PMID: 11747442

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135391 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit zeta Chains: A, C
Molecule details ›
Chains: A, C
Length: 142 amino acids
Theoretical weight: 15.55 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P02008 (Residues: 2-142; Coverage: 99%)
Gene names: HBZ, HBZ2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta-1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.64 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P02088 (Residues: 2-147; Coverage: 99%)
Gene name: Hbb-b1
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 4 x HEM
Ligand CMO 4 x CMO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P41
Unit cell:
a: 84.921Å b: 84.921Å c: 104.523Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.249
Expression system: Mus musculus

Quick links

Citations

2 review citations

Molecular aspects of embryonic hemoglobin function.
Brittain T. (2002)
1 more

3 mentions without citation

Exploring the common dynamics of homologous proteins. Application to the globin family.
Maguid et al. (2005)
2 more