› 1jew

Electron Microscopy
22Å resolution

CRYO-EM STRUCTURE OF COXSACKIEVIRUS B3(M STRAIN) WITH ITS CELLULAR RECEPTOR, COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR (CAR).

Released:
DOI: 10.2210/pdb1jew/pdb
PDB entry 1jew coloured by chain, front view.
PDB entry 1jew coloured by chain, side view.
PDB entry 1jew coloured by chain, top view.
Source organisms:
Primary publication:
Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor.
He Y, Chipman PR, Howitt J, Bator CM, Whitt MA, Baker TS, Kuhn RJ, Anderson CW, Freimuth P, Rossmann MG
Nat Struct Biol 8 874-8 (2001)
PMID: 11573093

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160227 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Coxsackievirus and adenovirus receptor Chain: R
Molecule details ›
Chain: R
Length: 120 amino acids
Theoretical weight: 13.36 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P78310 (Residues: 21-140; Coverage: 35%)
Gene names: CAR, CXADR
Sequence domains: Immunoglobulin V-set domain
Capsid protein VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 281 amino acids
Theoretical weight: 31.38 KDa
Source organism: Coxsackievirus B3 (strain Woodruff)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q66282 (Residues: 571-851; Coverage: 13%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 263 amino acids
Theoretical weight: 28.88 KDa
Source organism: Coxsackievirus B3 (strain Woodruff)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q66282 (Residues: 70-332; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: 3
Molecule details ›
Chain: 3
Length: 238 amino acids
Theoretical weight: 26.2 KDa
Source organism: Coxsackievirus B3 (strain Woodruff)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q66282 (Residues: 333-570; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP4 Chain: 4
Molecule details ›
Chain: 4
Length: 68 amino acids
Theoretical weight: 7.38 KDa
Source organism: Coxsackievirus B3 (strain Woodruff)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q66282 (Residues: 2-69; Coverage: 3%)
Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 22Å
Expression systems:
  • Mus musculus
  • Homo sapiens

Quick links

Citations

27 review citations

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe et al. (2021)
26 more

8 mentions without citation

Virus-Receptor Interactions: Structural Insights For Oncolytic Virus Development.
Jayawardena et al. (2019)
7 more