› 1jhl

X-ray diffraction
2.4Å resolution

THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX

Released:
DOI: 10.2210/pdb1jhl/pdb
PDB entry 1jhl coloured by chain, front view.
PDB entry 1jhl coloured by chain, side view.
PDB entry 1jhl coloured by chain, top view.
Source organisms:
Primary publication:
Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex.
Chitarra V, Alzari PM, Bentley GA, Bhat TN, Eiselé JL, Houdusse A, Lescar J, Souchon H, Poljak RJ
Proc Natl Acad Sci U S A 90 7711-5 (1993)
PMID: 8356074

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208284 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IGG1-KAPPA D11.15 FV (LIGHT CHAIN) Chain: L
Molecule details ›
Chain: L
Length: 108 amino acids
Theoretical weight: 11.84 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
IGG1-KAPPA D11.15 FV (HEAVY CHAIN) Chain: H
Molecule details ›
Chain: H
Length: 116 amino acids
Theoretical weight: 13 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
Lysozyme C Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.28 KDa
Source organism: Phasianus colchicus
Expression system: Not provided
UniProt:
  • Canonical: P00702 (Residues: 19-147; Coverage: 99%)
Gene name: LYZ
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P65
Unit cell:
a: 57.8Å b: 57.8Å c: 282.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.214 not available
Expression system: Not provided

Quick links

Citations

6 review citations

Interactions of protein antigens with antibodies.
Davies et al. (1996)
5 more

37 mentions without citation

The structural basis of antibody-antigen recognition.
Sela-Culang et al. (2013)
36 more