› 1jhw

X-ray diffraction
2.8Å resolution

Ca2+-binding Mimicry in the Crystal Structure of the Eu3+-Bound Mutant Human Macrophage Capping Protein Cap G

Released:
DOI: 10.2210/pdb1jhw/pdb
PDB entry 1jhw coloured by chain, front view.
PDB entry 1jhw coloured by chain, side view.
PDB entry 1jhw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vorobiev SM, Southwick FS, Almo SC

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-154030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage-capping protein Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 38.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40121 (Residues: 1-348; Coverage: 100%)
Gene names: AFCP, CAPG, MCP
Sequence domains: Gelsolin repeat
Structure domains: Severin

Ligands and Environments

1 bound ligand:
Ligand EU3 2 x EU3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P6322
Unit cell:
a: 205.596Å b: 205.596Å c: 56.42Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.248 0.296
Expression system: Escherichia coli

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