› 1jia

X-ray diffraction
2.13Å resolution

STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION

Released:
DOI: 10.2210/pdb1jia/pdb
PDB entry 1jia coloured by chain, front view.
PDB entry 1jia coloured by chain, side view.
PDB entry 1jia coloured by chain, top view.
Source organism: Gloydius halys
Primary publication:
Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 A resolution.
Zhao K, Song S, Lin Z, Zhou Y
Acta Crystallogr D Biol Crystallogr 54 510-21 (1998)
PMID: 9761847

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 B Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 13.92 KDa
Source organism: Gloydius halys
UniProt:
  • Canonical: O42187 (Residues: 18-138; Coverage: 99%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 97.13Å b: 103.69Å c: 23.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.152 0.255

Quick links

Citations

2 review citations

Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis.
Chioato et al. (2003)
1 more

7 mentions without citation

The chemistry of snake venom and its medicinal potential.
Oliveira et al. (2022)
6 more