› 1jiq

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Autocrine Motility Factor

Released:
DOI: 10.2210/pdb1jiq/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1jiq coloured by chain, front view.
PDB entry 1jiq coloured by chain, side view.
PDB entry 1jiq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies.
Tanaka N, Haga A, Uemura H, Akiyama H, Funasaka T, Nagase H, Raz A, Nakamura KT
J Mol Biol 318 985-97 (2002)
PMID: 12054796

Function and Biology Details

Reaction catalysed: 
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucose-6-phosphate isomerase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 558 amino acids
Theoretical weight: 63.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06744 (Residues: 1-558; Coverage: 100%)
Gene name: GPI
Sequence domains: Phosphoglucose isomerase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE BL-18B
Spacegroup: P212121
Unit cell:
a: 80.77Å b: 107.4Å c: 270.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.198
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy.
Iiizumi et al. (2008)
2 more

1 mention without citation

Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1.
Li et al. (2019)