› 1jlh

X-ray diffraction
2.1Å resolution

Human Glucose-6-phosphate Isomerase

Released:
DOI: 10.2210/pdb1jlh/pdb
PDB entry 1jlh coloured by chain, front view.
PDB entry 1jlh coloured by chain, side view.
PDB entry 1jlh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps.
Cordeiro AT, Godoi PH, Silva CH, Garratt RC, Oliva G, Thiemann OH
Biochim Biophys Acta 1645 117-22 (2003)
PMID: 12573240

Function and Biology Details

Reaction catalysed: 
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucose-6-phosphate isomerase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 558 amino acids
Theoretical weight: 63.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06744 (Residues: 1-558; Coverage: 100%)
Gene name: GPI
Sequence domains: Phosphoglucose isomerase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 80.75Å b: 108.021Å c: 271.073Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 citation in other articles

Detection of new pathogenic mutations in patients with congenital haemolytic anaemia using next-generation sequencing.
Del Orbe Barreto et al. (2016)
10 more

8 mentions without citation

Inverse docking based screening and identification of protein targets for Cassiarin alkaloids against Plasmodium falciparum.
Negi et al. (2018)
7 more