› 1jlp

Solution NMR

Solution Structure of the Noncompetitive Skeletal Muscle Nicotinic Acetylcholine Receptor Antagonist Psi-conotoxin PIIIF

Released:
DOI: 10.2210/pdb1jlp/pdb
PDB entry 1jlp coloured by chain, ensemble of 17 models, front view.
PDB entry 1jlp coloured by chain, ensemble of 17 models, side view.
PDB entry 1jlp coloured by chain, ensemble of 17 models, top view.
Source organism: Conus purpurascens
Primary publication:
Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors.
Van Wagoner RM, Jacobsen RB, Olivera BM, Ireland CM
Biochemistry 42 6353-62 (2003)
PMID: 12767216

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Psi-conotoxin PIIIF Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.67 KDa
Source organism: Conus purpurascens
Expression system: Not provided
UniProt:
  • Canonical: P60245 (Residues: 1-24; Coverage: 100%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 4 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry molecular dynamics relaxation matrix distance geometry simulated annealing
Expression system: Not provided

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Citations

7 review citations

Conus venoms: a rich source of novel ion channel-targeted peptides.
Terlau et al. (2004)
6 more

2 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
1 more