› 1jo1

Solution NMR

N7-Guanine Adduct of 2,7-diaminomitosene with DNA

Released:
DOI: 10.2210/pdb1jo1/pdb
PDB entry 1jo1 coloured by chain, front view.
PDB entry 1jo1 coloured by chain, side view.
PDB entry 1jo1 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.
Subramaniam G, Paz MM, Suresh Kumar G, Das A, Palom Y, Clement CC, Patel DJ, Tomasz M
Biochemistry 40 10473-84 (2001)
PMID: 11523988

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114020 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DAJ 2 x DAJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry and molecular dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.
Bass et al. (2013)
5 other articles

2 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
1 more