› 1jpq

X-ray diffraction
1.6Å resolution

Crystal Structure of the Oxytricha Telomeric DNA at 1.6A

Released:
DOI: 10.2210/pdb1jpq/pdb
PDB entry 1jpq coloured by chain, front view.
PDB entry 1jpq coloured by chain, side view.
PDB entry 1jpq coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex.
Haider S, Parkinson GN, Neidle S
J Mol Biol 320 189-200 (2002)
PMID: 12079378

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114021 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*GP*GP*GP*(BRU)P*TP*TP*TP*GP*GP*GP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.87 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand K 5 x K
1 modified residue:
Ligand BRU 2 x BRU

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P3221
Unit cell:
a: 27.543Å b: 27.543Å c: 145.817Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.225 0.276
Expression system: Not provided

Quick links

Citations

25 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
24 more

26 mentions without citation

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
25 more