› 1jpx

X-ray diffraction
2.3Å resolution

Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Wild type.

Released:
DOI: 10.2210/pdb1jpx/pdb
PDB entry 1jpx coloured by chain, front view.
PDB entry 1jpx coloured by chain, side view.
PDB entry 1jpx coloured by chain, top view.
Source organism: Simian immunodeficiency virus
Primary publication:
Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
Liu J, Wang S, Hoxie JA, LaBranche CC, Lu M
J Biol Chem 277 12891-900 (2002)
PMID: 11830586

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein gp160 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 84 amino acids
Theoretical weight: 9.86 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: S4WCF9 (Residues: 555-594, 637-674; Coverage: 9%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P63
Unit cell:
a: 54.993Å b: 54.993Å c: 131.14Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.237 0.283
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Membrane fusion.
Jahn et al. (2003)
1 more