› 1jq0

X-ray diffraction
1.7Å resolution

Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Mutant structure.

Released:
DOI: 10.2210/pdb1jq0/pdb
PDB entry 1jq0 coloured by chain, front view.
PDB entry 1jq0 coloured by chain, side view.
PDB entry 1jq0 coloured by chain, top view.
Source organism: Simian immunodeficiency virus
Primary publication:
Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
Liu J, Wang S, Hoxie JA, LaBranche CC, Lu M
J Biol Chem 277 12891-900 (2002)
PMID: 11830586

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein gp160 Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.84 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: S4WCF9 (Residues: 555-594, 637-674; Coverage: 9%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: R32
Unit cell:
a: 48.877Å b: 48.877Å c: 150.987Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.209 0.252
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Membrane fusion.
Jahn et al. (2003)
1 more