› 1jqg

X-ray diffraction
2.5Å resolution

Crystal Structure of the Carboxypeptidase A from Helicoverpa Armigera

Released:
DOI: 10.2210/pdb1jqg/pdb
PDB entry 1jqg coloured by chain, front view.
PDB entry 1jqg coloured by chain, side view.
PDB entry 1jqg coloured by chain, top view.
Source organism: Helicoverpa armigera
Primary publication:
Crystal structure of a novel mid-gut procarboxypeptidase from the cotton pest Helicoverpa armigera.
Estébanez-Perpiñá E, Bayés A, Vendrell J, Jongsma MA, Bown DP, Gatehouse JA, Huber R, Bode W, Avilés FX, Reverter D
J Mol Biol 313 629-38 (2001)
PMID: 11676544

Function and Biology Details

Reaction catalysed: 
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase M14 carboxypeptidase A domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 48.54 KDa
Source organism: Helicoverpa armigera
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O97389 (Residues: 1-433; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 48.03Å b: 86.39Å c: 50.55Å
α: 90° β: 100.7° γ: 90°
R-values:
R R work R free
0.18 0.18 0.238
Expression system: Komagataella pastoris

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Citations

1 review citation

Structural and functional diversities in lepidopteran serine proteases.
Srinivasan et al. (2006)
12 other articles

3 mentions without citation

Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism.
Gavor et al. (2021)
2 more