› 1jqy

X-ray diffraction
2.14Å resolution

HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010

Released:
DOI: 10.2210/pdb1jqy/pdb
PDB entry 1jqy coloured by chain, front view.
PDB entry 1jqy coloured by chain, side view.
PDB entry 1jqy coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E
Chem Biol 9 215-24 (2002)
PMID: 11880036

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat-labile enterotoxin B chain Chains: D, E, F, G, H, L, M, N, O, P, V, W, X, Y, Z
Molecule details ›
Chains: D, E, F, G, H, L, M, N, O, P, V, W, X, Y, Z
Length: 103 amino acids
Theoretical weight: 11.81 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P32890 (Residues: 22-124; Coverage: 100%)
Gene names: eltB, ltpB
Sequence domains: Heat-labile enterotoxin beta chain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand A32 14 x A32
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 64.99Å b: 166.006Å c: 74.42Å
α: 90° β: 92.13° γ: 90°
R-values:
R R work R free
0.211 0.211 0.284
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Design and creativity in synthesis of multivalent neoglycoconjugates.
Chabre et al. (2010)
5 more

1 mention without citation

Identification of the ligand binding sites on the molecular surface of proteins.
Kinoshita et al. (2005)