› 1js6

X-ray diffraction
2.6Å resolution

Crystal Structure of DOPA decarboxylase

Released:
DOI: 10.2210/pdb1js6/pdb
PDB entry 1js6 coloured by chain, front view.
PDB entry 1js6 coloured by chain, side view.
PDB entry 1js6 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN
Nat Struct Biol 8 963-7 (2001)
PMID: 11685243

Function and Biology Details

Reaction catalysed: 
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160337 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aromatic-L-amino-acid decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 486 amino acids
Theoretical weight: 54 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: P80041 (Residues: 1-486; Coverage: 100%)
Gene name: DDC
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain
Structure domains:

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM1A
Spacegroup: P62
Unit cell:
a: 152.86Å b: 152.86Å c: 86.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.206 0.258
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Biogenic amines and polyamines: similar biochemistry for different physiological missions and biomedical applications.
Medina et al. (2003)
20 more

8 mentions without citation

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Giardina et al. (2011)
7 more