› 1jsg

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY

Released:
DOI: 10.2210/pdb1jsg/pdb
PDB entry 1jsg coloured by chain, front view.
PDB entry 1jsg coloured by chain, side view.
PDB entry 1jsg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H
Structure 6 147-55 (1998)
PMID: 9519406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157457 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell leukemia/lymphoma protein 1A Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56279 (Residues: 1-114; Coverage: 100%)
Gene names: TCL1, TCL1A
Sequence domains: TCL1/MTCP1 family
Structure domains: TCL1/MTCP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I222
Unit cell:
a: 38.897Å b: 82.839Å c: 117.726Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.259

Quick links

Citations

7 review citations

The TCL1 family of oncoproteins: co-activators of transformation.
Teitell MA. (2005)
6 more

7 mentions without citation

Identification of protein oligomerization states by analysis of interface conservation.
Elcock et al. (2001)
6 more