› 1jv8

Solution NMR

NMR Structure of BPTI Mutant G37A

Released:
DOI: 10.2210/pdb1jv8/pdb
PDB entry 1jv8 coloured by chain, ensemble of 23 models, front view.
PDB entry 1jv8 coloured by chain, ensemble of 23 models, side view.
PDB entry 1jv8 coloured by chain, ensemble of 23 models, top view.
Source organism: Bos taurus
Primary publication:
A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.
Battiste JL, Li R, Woodward C
Biochemistry 41 2237-45 (2002)
PMID: 11841215

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pancreatic trypsin inhibitor Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.54 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00974 (Residues: 36-93; Coverage: 73%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

13 citation in other articles

Accounting for loop flexibility during protein-protein docking.
Bastard et al. (2006)
12 more

3 mentions without citation

Systematic comparison of crystal and NMR protein structures deposited in the protein data bank.
Sikic et al. (2010)
2 more