Function and Biology Details
Reaction catalysed:
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Caspase-9 subunit p35 and peptide (preferred)
PDBe Complex ID:
PDB-CPX-157267 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Caspase-9 subunit p35
Molecule details ›
Chains: A, B, C, D
Length: 284 amino acids
Theoretical weight: 31.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Length: 284 amino acids
Theoretical weight: 31.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P55211 (Residues: 139-416; Coverage: 67%)
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRL BEAMLINE BL7-1
Spacegroup:
C2
Expression systems:
- Escherichia coli
- Not provided
