› 1jxs

Solution NMR

Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor

Released:
DOI: 10.2210/pdb1jxs/pdb
PDB entry 1jxs coloured by chain, ensemble of 20 models, front view.
PDB entry 1jxs coloured by chain, ensemble of 20 models, side view.
PDB entry 1jxs coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).
Liu PP, Chen YC, Li C, Hsieh YH, Chen SW, Chen SH, Jeng WY, Chuang WJ
Proteins 49 543-53 (2002)
PMID: 12402362

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Forkhead box protein K2 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q01167 (Residues: 256-353; Coverage: 15%)
Gene names: FOXK2, ILF, ILF1
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Hybrid distance geometry-dynamical simulated annealing method
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Structure/function relationships underlying regulation of FOXO transcription factors.
Obsil et al. (2008)
1 more

3 mentions without citation

Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins.
Hegyi et al. (2009)
2 more