› 1jxv

X-ray diffraction
2.2Å resolution

Crystal Structure of Human Nucleoside Diphosphate Kinase A

Released:
DOI: 10.2210/pdb1jxv/pdb
PDB entry 1jxv coloured by chain, front view.
PDB entry 1jxv coloured by chain, side view.
PDB entry 1jxv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor.
Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW
Proteins 46 340-2 (2002)
PMID: 11835509

Function and Biology Details

Reaction catalysed: 
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate kinase A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 152 amino acids
Theoretical weight: 17.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15531 (Residues: 1-152; Coverage: 100%)
Gene names: NDPKA, NM23, NME1
Sequence domains: Nucleoside diphosphate kinase
Structure domains: Nucleoside diphosphate kinase-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P21
Unit cell:
a: 74.21Å b: 78.11Å c: 82.29Å
α: 90° β: 101.33° γ: 90°
R-values:
R R work R free
0.207 0.207 0.263
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

The mammalian Nm23/NDPK family: from metastasis control to cilia movement.
Boissan et al. (2009)
3 more

12 mentions without citation

NME/NM23/NDPK and Histidine Phosphorylation.
Adam et al. (2020)
11 more