› 1jy1

X-ray diffraction
1.69Å resolution

CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)

Released:
DOI: 10.2210/pdb1jy1/pdb
PDB entry 1jy1 coloured by chain, front view.
PDB entry 1jy1 coloured by chain, side view.
PDB entry 1jy1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1.
Davies DR, Interthal H, Champoux JJ, Hol WG
Structure 10 237-48 (2002)
PMID: 11839309

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosyl-DNA phosphodiesterase 1 Chain: A
Molecule details ›
Chain: A
Length: 464 amino acids
Theoretical weight: 52.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NUW8 (Residues: 149-608; Coverage: 76%)
Gene name: TDP1
Sequence domains: Tyrosyl-DNA phosphodiesterase
Structure domains: Endonuclease Chain A

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 186.445Å b: 52.03Å c: 56.313Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.229
Expression system: Escherichia coli BL21

Quick links

Citations

26 review citations

Targeting DNA topoisomerase II in cancer chemotherapy.
Nitiss JL. (2009)
25 more

11 mentions without citation

Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.
Kawale et al. (2018)
10 more