› 1k0n

X-ray diffraction
1.8Å resolution

Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione

Released:
DOI: 10.2210/pdb1k0n/pdb
PDB entry 1k0n coloured by chain, front view.
PDB entry 1k0n coloured by chain, side view.
PDB entry 1k0n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
Harrop SJ, DeMaere MZ, Fairlie WD, Reztsova T, Valenzuela SM, Mazzanti M, Tonini R, Qiu MR, Jankova L, Warton K, Bauskin AR, Wu WM, Pankhurst S, Campbell TJ, Breit SN, Curmi PM
J Biol Chem 276 44993-5000 (2001)
PMID: 11551966

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride intracellular channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 241 amino acids
Theoretical weight: 26.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00299 (Residues: 1-241; Coverage: 100%)
Gene names: CLIC1, G6, NCC27
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GSH 1 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 46.509Å b: 60.355Å c: 89.627Å
α: 90° β: 92.5° γ: 90°
R-values:
R R work R free
0.252 0.251 0.281
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Glutathione transferases.
Hayes et al. (2005)
27 more

9 mentions without citation

The still mysterious roles of cysteine-containing glutathione transferases in plants.
Lallement et al. (2014)
8 more