› 1k0o

X-ray diffraction
1.75Å resolution

Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel

Released:
DOI: 10.2210/pdb1k0o/pdb
PDB entry 1k0o coloured by chain, front view.
PDB entry 1k0o coloured by chain, side view.
PDB entry 1k0o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
Harrop SJ, DeMaere MZ, Fairlie WD, Reztsova T, Valenzuela SM, Mazzanti M, Tonini R, Qiu MR, Jankova L, Warton K, Bauskin AR, Wu WM, Pankhurst S, Campbell TJ, Breit SN, Curmi PM
J Biol Chem 276 44993-5000 (2001)
PMID: 11551966

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride intracellular channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 241 amino acids
Theoretical weight: 26.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00299 (Residues: 1-241; Coverage: 100%)
Gene names: CLIC1, G6, NCC27
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P21
Unit cell:
a: 46.408Å b: 60.311Å c: 89.428Å
α: 90° β: 92.41° γ: 90°
R-values:
R R work R free
0.242 0.24 0.268
Expression system: Escherichia coli

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Citations

29 review citations

Glutathione transferases.
Hayes et al. (2005)
28 more

5 mentions without citation

Functional and Regulatory Roles of Fold-Switching Proteins.
Kim et al. (2021)
4 more