› 1k12

X-ray diffraction
1.9Å resolution

Fucose Binding lectin

Released:
DOI: 10.2210/pdb1k12/pdb
PDB entry 1k12 coloured by chain, front view.
PDB entry 1k12 coloured by chain, side view.
PDB entry 1k12 coloured by chain, top view.
Source organism: Anguilla anguilla
Primary publication:
A novel fucose recognition fold involved in innate immunity.
Bianchet MA, Odom EW, Vasta GR, Amzel LM
Nat Struct Biol 9 628-34 (2002)
PMID: 12091873

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fucolectin Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 16.91 KDa
Source organism: Anguilla anguilla
UniProt:
  • Canonical: Q7SIC1 (Residues: 1-158; Coverage: 100%)
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

3 bound ligands:
Ligand FUC 1 x FUC
Ligand CA 1 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: R32
Unit cell:
a: 65.54Å b: 65.54Å c: 245.136Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.19 0.239

Quick links

Citations

11 review citations

Roles of galectins in infection.
Vasta GR. (2009)
10 more

15 mentions without citation

Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.
Vasta et al. (2011)
14 more