› 1k1h

Solution NMR

HETERODUPLEX OF CHIRALLY PURE METHYLPHOSPHONATE/DNA DUPLEX

Released:
DOI: 10.2210/pdb1k1h/pdb
PDB entry 1k1h coloured by chain, front view.
PDB entry 1k1h coloured by chain, side view.
PDB entry 1k1h coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure of hybrid backbone methylphosphonate DNA heteroduplexes: effect of R and S stereochemistry.
Thiviyanathan V, Vyazovkina KV, Gozansky EK, Bichenchova E, Abramova TV, Luxon BA, Lebedev AV, Gorenstein DG
Biochemistry 41 827-38 (2002)
PMID: 11790104

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114039 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*TP*GP*TP*TP*TP*GP*GP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.45 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*(CMR)P*(RMP)P*(RMP)P*(SMP)P*(CMR)P*(RMP))-3' Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.06 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand CMR 2 x CMR
Ligand RMP 3 x RMP
Ligand SMP 1 x SMP

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics matrix relaxation
Expression system: Not provided

Quick links

Citations

3 review citations

Chirality as a tool in nucleic acid recognition: principles and relevance in biotechnology and in medicinal chemistry.
Corradini et al. (2007)
2 more