› 1k2l

X-ray diffraction
2.4Å resolution

STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX

Released:
DOI: 10.2210/pdb1k2l/pdb
PDB entry 1k2l coloured by chain, front view.
PDB entry 1k2l coloured by chain, side view.
PDB entry 1k2l coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex.
Teixeira SC, Thorpe JH, Todd AK, Powell HR, Adams A, Wakelin LP, Denny WA, Cardin CJ
J Mol Biol 323 167-71 (2002)
PMID: 12381312

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114044 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*TP*AP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CO 2 x CO
Ligand BDC 1 x BDC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: C222
Unit cell:
a: 29.507Å b: 53.738Å c: 40.061Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.327 0.239 0.309
Expression system: Not provided

Quick links

Citations

4 review citations

Supramolecular DNA recognition.
Hannon MJ. (2007)
3 more

3 mentions without citation

Major Achievements in the Design of Quadruplex-Interactive Small Molecules.
Mendes et al. (2022)
2 more