› 1k5e

Solution NMR

Solution Structure of R-styrene Adduct in the Ras61 Sequence

Released:
DOI: 10.2210/pdb1k5e/pdb
PDB entry 1k5e coloured by chain, front view.
PDB entry 1k5e coloured by chain, side view.
PDB entry 1k5e coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.
Hennard C, Finneman J, Harris CM, Harris TM, Stone MP
Biochemistry 40 9780-91 (2001)
PMID: 11502171

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114051 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*GP*GP*AP*CP*(ABR)P*AP*GP*AP*AP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.54 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.29 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ABR 1 x ABR

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, matrix relaxation
Expression system: Not provided

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Citations

4 review citations

Biological properties of single chemical-DNA adducts: a twenty year perspective.
Delaney et al. (2008)
3 more