› 1k6j

X-ray diffraction
1.8Å resolution

Crystal structure of Nmra, a negative transcriptional regulator (Monoclinic form)

Released:
DOI: 10.2210/pdb1k6j/pdb
PDB entry 1k6j coloured by chain, front view.
PDB entry 1k6j coloured by chain, side view.
PDB entry 1k6j coloured by chain, top view.
Source organism: Aspergillus nidulans
Primary publication:
The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, Hawkins AR
EMBO J 20 6619-26 (2001)
PMID: 11726498

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176884 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nitrogen metabolite repression protein nmrA Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 38.84 KDa
Source organism: Aspergillus nidulans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5AU62 (Residues: 1-352; Coverage: 100%)
Gene names: AN8168, nmrA
Sequence domains: NmrA-like family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 7 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 148.8Å b: 64.3Å c: 110.2Å
α: 90° β: 121.8° γ: 90°
R-values:
R R work R free
0.164 0.165 0.202
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
Kavanagh et al. (2008)
4 more

1 mention without citation

The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
Stammers et al. (2001)