› 1k8l

Solution NMR

XBY6: An analog of CK14 containing 6 dithiophosphate groups

Released:
DOI: 10.2210/pdb1k8l/pdb
PDB entry 1k8l coloured by chain, front view.
PDB entry 1k8l coloured by chain, side view.
PDB entry 1k8l coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure and design of dithiophosphate backbone aptamers targeting transcription factor NF-kappaB.
Volk DE, Yang X, Fennewald SM, King DJ, Bassett SE, Venkitachalam S, Herzog N, Luxon BA, Gorenstein DG
Bioorg Chem 30 396-419 (2002)
PMID: 12642125

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114062 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
FIRST STRAND OF CK14 DNA DUPLEX Chain: A
Molecule details ›
Chain: A
Length: 14 nucleotides
Theoretical weight: 4.31 KDa
Source organism: Synthetic construct
Expression system: Not provided
SECOND STRAND OF CK14 DNA DUPLEX Chain: B
Molecule details ›
Chain: B
Length: 14 nucleotides
Theoretical weight: 4.44 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand T2S 1 x T2S
Ligand C2S 3 x C2S
Ligand G2S 2 x G2S

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

Aptamer Therapeutics in Cancer: Current and Future.
Morita et al. (2018)
3 more