› 1k8p

X-ray diffraction
2.4Å resolution

Structure of the Human G-quadruplex reveals a novel topology

Released:
DOI: 10.2210/pdb1k8p/pdb
PDB entry 1k8p coloured by chain, front view.
PDB entry 1k8p coloured by chain, side view.
PDB entry 1k8p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of parallel quadruplexes from human telomeric DNA.
Parkinson GN, Lee MP, Neidle S
Nature 417 876-80 (2002)
PMID: 12050675

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114064 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*(BRU)P*AP*GP*GP*GP*(BRU)P*TP*AP*GP*GP*GP*T)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.9 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 2 x K
Ligand NA 1 x NA
1 modified residue:
Ligand BRU 4 x BRU

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 56.607Å b: 56.607Å c: 40.546Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.189 0.28
Expression system: Not provided

Quick links

Citations

142 review citations

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
141 more

18 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
17 more