› 1kc4

Solution NMR

NMR Structural Analysis of the Complex Formed Between alpha-Bungarotoxin and the Principal alpha-Neurotoxin Binding Sequence on the alpha7 Subunit of a Neuronal Nicotinic Acetylcholine Receptor

Released:
DOI: 10.2210/pdb1kc4/pdb
PDB entry 1kc4 coloured by chain, ensemble of 10 models, front view.
PDB entry 1kc4 coloured by chain, ensemble of 10 models, side view.
PDB entry 1kc4 coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.
Moise L, Piserchio A, Basus VJ, Hawrot E
J Biol Chem 277 12406-17 (2002)
PMID: 11790782

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149797 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-bungarotoxin Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.01 KDa
Source organism: Bungarus multicinctus
UniProt:
  • Canonical: P60615 (Residues: 22-95; Coverage: 100%)
Structure domains: CD59
Neuronal acetylcholine receptor subunit alpha-7 Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.35 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22770 (Residues: 201-219; Coverage: 4%)
Gene name: CHRNA7

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HSL 1 x HSL

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry dynamical simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.
Kalamida et al. (2007)
9 more

3 mentions without citation

Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion Channel.
Cosseddu et al. (2021)
2 more