› 1kci

X-ray diffraction
1.8Å resolution

Crystal Structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide Bound to d(CGTACG)2

Released:
DOI: 10.2210/pdb1kci/pdb
PDB entry 1kci coloured by chain, front view.
PDB entry 1kci coloured by chain, side view.
PDB entry 1kci coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons.
Adams A, Guss JM, Denny WA, Wakelin LP
Nucleic Acids Res 30 719-25 (2002)
PMID: 11809884

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114076 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*TP*AP*CP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DRC 2 x DRC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P64
Unit cell:
a: 30.239Å b: 30.239Å c: 39.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.215 0.291
Expression system: Not provided

Quick links

Citations

2 review citations

Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
Cholewiński et al. (2011)
1 more

6 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
5 more