› 1kdk

X-ray diffraction
1.7Å resolution

THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA

Released:
DOI: 10.2210/pdb1kdk/pdb
PDB entry 1kdk coloured by chain, front view.
PDB entry 1kdk coloured by chain, side view.
PDB entry 1kdk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
Grishkovskaya I, Avvakumov GV, Hammond GL, Muller YA
J Mol Biol 318 621-6 (2002)
PMID: 12054810

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex hormone-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 177 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04278 (Residues: 42-158, 165-217; Coverage: 46%)
Gene name: SHBG
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand DHT 1 x DHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: R32
Unit cell:
a: 103.72Å b: 103.72Å c: 85.76Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.194 0.245
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Diverse roles for sex hormone-binding globulin in reproduction.
Hammond GL. (2011)
3 more

4 mentions without citation

Mechanical strength of 17,134 model proteins and cysteine slipknots.
Sikora et al. (2009)
3 more