› 1kdx

Solution NMR

KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES

Released:
DOI: 10.2210/pdb1kdx/pdb
PDB entry 1kdx coloured by chain, ensemble of 17 models, front view.
PDB entry 1kdx coloured by chain, ensemble of 17 models, side view.
PDB entry 1kdx coloured by chain, ensemble of 17 models, top view.
Source organisms:
Primary publication:
Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions.
Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE
Cell 91 741-52 (1997)
PMID: 9413984

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147323 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone lysine acetyltransferase CREBBP Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.55 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45481 (Residues: 586-666; Coverage: 3%)
Gene names: Cbp, Crebbp
Sequence domains: KIX domain
Structure domains: Coactivator CBP, KIX domain
Cyclic AMP-responsive element-binding protein 1 Chain: B
Molecule details ›
Chain: B
Length: 28 amino acids
Theoretical weight: 3.39 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15337 (Residues: 105-132; Coverage: 9%)
Gene names: Creb-1, Creb1
Sequence domains: pKID domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
Refinement method: DG, SA
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

79 review citations

Intrinsically unstructured proteins and their functions.
Dyson et al. (2005)
78 more

55 mentions without citation

Malleable machines take shape in eukaryotic transcriptional regulation.
Fuxreiter et al. (2008)
54 more