› 1keo

X-ray diffraction
2.2Å resolution

TWISTS AND TURNS OF THE CD-MPR: LIGAND-BOUND VERSUS LIGAND-FREE RECEPTOR

Released:
DOI: 10.2210/pdb1keo/pdb
PDB entry 1keo coloured by chain, front view.
PDB entry 1keo coloured by chain, side view.
PDB entry 1keo coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor.
Olson LJ, Zhang J, Dahms NM, Kim JJ
J Biol Chem 277 10156-61 (2002)
PMID: 11786557

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145846 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cation-dependent mannose-6-phosphate receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 17.44 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P11456 (Residues: 29-182; Coverage: 61%)
Gene name: M6PR
Sequence domains: Mannose-6-phosphate receptor
Structure domains: Mannose-6-phosphate receptor binding domain

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I4
Unit cell:
a: 108.772Å b: 108.772Å c: 72.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.248
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

Signals for sorting of transmembrane proteins to endosomes and lysosomes.
Bonifacino et al. (2003)
6 more

2 mentions without citation

Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor.
Olson et al. (2008)
1 more