› 1kh6

X-ray diffraction
2.9Å resolution

Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.

Released:
DOI: 10.2210/pdb1kh6/pdb
PDB entry 1kh6 coloured by chain, front view.
PDB entry 1kh6 coloured by chain, side view.
PDB entry 1kh6 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation.
Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA
Nat Struct Biol 9 370-4 (2002)
PMID: 11927953

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196087 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
JIIIabc Chain: A
Molecule details ›
Chain: A
Length: 53 nucleotides
Theoretical weight: 17.63 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand 5BU 6 x 5BU

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P42212
Unit cell:
a: 66.532Å b: 66.532Å c: 95.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.283 0.283 0.279
Expression system: Not provided

Quick links

Citations

34 review citations

Structural biology of hepatitis C virus.
Penin et al. (2004)
33 more

17 mentions without citation

Structure and function of HCV IRES domains.
Lukavsky PJ. (2009)
16 more