› 1khx

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172406 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mothers against decapentaplegic homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 25.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15796 (Residues: 241-467; Coverage: 49%)
Gene names: MADH2, MADR2, SMAD2
Sequence domains: MH2 domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: I213
Unit cell:
a: 113.7Å b: 113.7Å c: 113.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.215 0.241
Expression system: Escherichia coli

Quick links

Citations

55 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
54 more

20 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
19 more