› 1kkd

Solution NMR

Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)

Released:
DOI: 10.2210/pdb1kkd/pdb
PDB entry 1kkd coloured by chain, ensemble of 23 models, front view.
PDB entry 1kkd coloured by chain, ensemble of 23 models, side view.
PDB entry 1kkd coloured by chain, ensemble of 23 models, top view.
Source organism: Rattus norvegicus
Primary publication:
A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin.
Wissmann R, Bildl W, Neumann H, Rivard AF, Klöcker N, Weitz D, Schulte U, Adelman JP, Bentrop D, Fakler B
J Biol Chem 277 4558-64 (2002)
PMID: 11723128

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small conductance calcium-activated potassium channel protein 2 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 12.24 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P70604 (Residues: 396-487; Coverage: 16%)
Gene name: Kcnn2
Sequence domains: Calmodulin binding domain
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli BL21(DE3)

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Citations

8 review citations

Calmodulin in action: diversity in target recognition and activation mechanisms.
Hoeflich et al. (2002)
7 more

3 mentions without citation

Do calmodulin binding IQ motifs have built-in capping domains?
Muguruza-Montero et al. (2021)
2 more