› 1kkh

X-ray diffraction
2.4Å resolution

Crystal Structure of the Methanococcus jannaschii Mevalonate Kinase

Released:
DOI: 10.2210/pdb1kkh/pdb
PDB entry 1kkh coloured by chain, front view.
PDB entry 1kkh coloured by chain, side view.
PDB entry 1kkh coloured by chain, top view.
Source organism: Methanocaldococcus jannaschii
Primary publication:
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily.
Yang D, Shipman LW, Roessner CA, Scott AI, Sacchettini JC
J Biol Chem 277 9462-7 (2002)
PMID: 11751891

Function and Biology Details

Reaction catalysed: 
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176626 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mevalonate kinase Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.77 KDa
Source organism: Methanocaldococcus jannaschii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q58487 (Residues: 1-312; Coverage: 100%)
Gene names: MJ1087, mvk
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand DIO 2 x DIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P21
Unit cell:
a: 56.138Å b: 44.028Å c: 64.845Å
α: 90° β: 102.71° γ: 90°
R-values:
R R work R free
0.228 0.2 0.282
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structure and function of enzymes of the Leloir pathway for galactose metabolism.
Holden et al. (2003)
6 more

8 mentions without citation

Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard.
Terwilliger et al. (2009)
7 more