› 1kl9

X-ray diffraction
1.9Å resolution

Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha

Released:
DOI: 10.2210/pdb1kl9/pdb
PDB entry 1kl9 coloured by chain, front view.
PDB entry 1kl9 coloured by chain, side view.
PDB entry 1kl9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.
Nonato MC, Widom J, Clardy J
J Biol Chem 277 17057-61 (2002)
PMID: 11859078

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-138583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2 subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05198 (Residues: 2-183; Coverage: 58%)
Gene names: EIF2A, EIF2S1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P2221
Unit cell:
a: 37.28Å b: 44.2Å c: 121.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.233
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Translational regulation of GCN4 and the general amino acid control of yeast.
Hinnebusch AG. (2005)
7 more

7 mentions without citation

Structural basis for the interaction of protein S1 with the Escherichia coli ribosome.
Byrgazov et al. (2015)
6 more