› 1kn7

Solution NMR

Solution structure of the tandem inactivation domain (residues 1-75) of potassium channel RCK4 (Kv1.4)

Released:
DOI: 10.2210/pdb1kn7/pdb
PDB entry 1kn7 coloured by chain, ensemble of 25 models, front view.
PDB entry 1kn7 coloured by chain, ensemble of 25 models, side view.
PDB entry 1kn7 coloured by chain, ensemble of 25 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4.
Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer HR, Bentrop D, Fakler B
J Biol Chem 278 16142-50 (2003)
PMID: 12590144

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147336 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily A member 4 Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 7.86 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15385 (Residues: 1-75; Coverage: 12%)
Gene name: Kcna4
Sequence domains: Potassium channel Kv1.4 tandem inactivation domain
Structure domains: Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment.
Judge et al. (2006)
5 more

2 mentions without citation

Heme impairs the ball-and-chain inactivation of potassium channels.
Sahoo et al. (2013)
1 more